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  PhysioMimix™ T1 Series Organs-on-Chips System

PhysioMimix™ T1 Series Organs-on-Chips System

Overview:


.The PhysioMimix™ system enables human cells to be cultured so that they mimic the structure and function of human organs and tissues.Allows for single-organ and multi-organ experiments with real-time control over cell culture conditions to mimic in vivo physiology.It can quickly and easily create three-dimensional living tissue and automatically control microfluidics, providing a long-term yield cell culture basis for information-rich analysis.

PhysioMimix™ T1 Series – Key Features


PhysioMimix™ combines flexibility in cell type and culture format for Organ-on-Chip 

experiments in a robust, easy to use instrument

Simple, flexible preparation of on-chip organ-mimetics PhysioMimix™ open-well MPS plates are compatible with commercial inserts, tissue-specific scaffolds and scaffoldfree cultures for easy scaling and onboarding of validated or bespoke model systems。

Design of experiment that fits your research needs

Easy seeding, dosing and sampling of cells and culture media in PhysioMimix™ openwell MPS plates. No PDMS components reduces non-specific binding giving you confidence in your results.

Long-term experiments, minimal user input

Automated microfluidics and flexibility over inter- and intra-organ flow rates enable longitudinal control over cell culture conditions, mimicry of dynamic biological processes and control of on-platform pharmacokinetics – at the push of a button。

 Your cells are precious, and so is your lab space PhysioMimix™ is a streamlined, low-footprint instrument compatible with the PhysioMimix™ suite of MPS plates enabling a single investment for a lifetime of high quality data-rich experiments. 

Application area :


Drug target discovery for e。g。 neuro, immune, metabolic diseases

Biomarker discovery

Personalised Medicine

Replacement of animal testing

Clinical trials in a dish

Regulatory testing: 

drugs, tobacco, cosmetics, chemicals

PhysioMimix™ T1 Series – Workflow


SEED 


• Any cells, easily seeded in open-well MPS plates

• Wide choice of culture formats including commercial inserts, organ slices, 

3D matrices and gels, tissue-specific scaffolds, scaffold-free cultures

• Easy on-boarding of bespoke or validated cell/tissue model systems 

including MucilAir™, EpiSkin™ and more

CULTURE


• Programmable fluidics。 Intra-organ flow rates adjustable to optimise oxygen, 

nutrients and mechanical forces

• Inter-organ flow rates easily optimised for accurate 

on-platform pharmacokinetics

• Media changes quickly and easily accomplished

DOSE


• Introduce biologics (peptides, proteins), small molecules, hormones and more

• Gene-editing (CRISPR, Talen, ZFN)

• Introduce immune cells (e.g. cytotoxic T cells, CAR-T, NK cells, etc) for 

immunological assays and insights

• No PDMS components to minimise non-specific binding

ANALYZE

• Easy (repeat) media sampling for biomarker assays (LC-MS, ELISA, multiplex) 

from open well plates

• Removable scaffolds allow micro tissues to be analysed by full range of 

-omics approaches

• Tissue mimetics can be taken for imaging to visualize cell morphology, cell 

migration and protein marker localizati

Specifications :


PhysioMimix™ T1 Controller —Controller capable of parallel operation of up to 12 MPS plates mounted on 4 Docking 

StationsPhysioMimix™ DS3 Docking Stati—Docking Station links to the Controller via a slim cable to the Controller。 Acts as an interface between the PhysioMimix MPS Driver and Controller

PhysioMimix™ MPSDriver—One MPS plate per MPS Driver

Reference list


[Infectious disease] Ortega-Prieto AM et al. 3D microfluidic liver cultures as a physiological preclinical tool for hepatitis B virus infection. Nat Commun. 2018 Feb; 9:pp-pp.

[Diabetes and NASH] Kostrzewski T et al。 Three-dimensional perfused human in vitro model of non-alcoholic fatty liver disease。 World J Gastroenterol 2017; 23(2): 204-215

[Oncology] Wheeler SE et al. Spontaneous dormancy of metastatic breast cancer cells in an all human liver microphysiologic system. Br J Cancer 2014; 111(12): 2342-2350

[2-Organs] Dalrymple A et al. The characterisation of a human two Organ-on- a-Chip (lung-liver) system which has the potential to measure systemic responses in vitro. Poster presented at Society of Toxicology 57th Annual meeting; 2018 Mar 11-15: San Antonio, Texas.

[4/7/10-Organs] Edington et al. Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies. Sci Rep, 2018. IN PRESS[Drug Safety] Long TJ et al. Modeling Therapeutic Antibody-Small Molecule Drug- Drug Interactions Using a Three-Dimensional Perfusable Human Liver Coculture Platform. Drug Metab Dispos 2016; 44(12): 1940-1948

[Drug Metabolism] Vivares A et al. Morphological behaviour and metabolic capacity of cryopreserved human primary hepatocytes cultivated in a perfused multiwell device. Xenobiotica 2015; 45(1): 29-44

[Drug Metabolism] Tsamandouras N et al. Quantitative Assessment of Population Variability in Hepatic Drug Metabolism Using a Perfused Three-Dimensional Human Liver Microphysiological System. J Pharmacol Exp Ther 2017; 360(1): 95-105

 


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