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  NuPET™ MR-Compatible Preclinical PET Scanner

NuPET™  MR-Compatible Preclinical PET Scanner

Overview:


    A revolutionary MR-compatible PET scanner for PET/MR imaging, allowing simultaneous measurement of molecular and functional processes in vivo。 Cubresa’s NuPET™ is a revolutionary in-bore PET scanner that inserts into existing MRI instruments to create a powerful and flexible hybrid preclinical imaging platform that combines the superior anatomical, structural, and functional information of MRI with the molecular sensitivity of PET。 Researchers using simultaneous PET/MRI imaging can measure multiple physiological processes concurrently with exceptional tissue contrast, quantitative accuracy and study throughput。 Sequential PET/MRI scanning captures data at different times, making it difficult to analyze important functional

relationships when animal physiology can change within minutes. With NuPET’s simultaneous scanning, MRI and PET work in unison to capture time-synchronized and highly complementary information previously unattainable – so you can trailblaze a path to a new discovery.

NuPET™ Technical feature:


√ Simultaneous whole-body mouse andrat-brain imaging while inside your MRI 

√ Supports a wide range of MRI systems, including high-field models, and the use of small-animal gradients √ Available standalone PET operation

√  Automatic PET/MRI co-registration

√  Industry’s smallest footprint

Exceptionally precise PET/MRI co-registration and paired PET and MRI data points unleash advances like MRI-based motion and partial volume corrections that increase PET quantification accuracy。 With MRI’s high soft-tissue contrast, VOIs can be accurately drawn using anatomical data with no guesswork。 Shorter anesthesia duration helps minimize animal stress and the risk of inducing physiological changes that can affect study quality。

Technology principle:


For the Biotic Installation, Cubresa made a larger sleeve that fits over the PET Insert. This sleeve has an inflatable rubber tube that can be pumped up. This large sleeve fits within 2 or 3 mm of the MRI bore size, which then allows the rubber sleeve to be pumped up to hold the PET Insert in place and to mitigate vibration effects.

Workflow for this system includes tuning rods for the MRI coils that exit from the front. This allows the animal, animal handling, animal positioning and tuning all to be done from the front of the MRI, saving time and hassle. For this MRI mechanical arrangement, a support and lock bar was designed to allow a customized fit to some customized hardware that is in the bore.

Application:


              Neuroscience—cause-and-effect, receptor activity, functional pharmacology

              Oncology—tumor characterization and therapy-response assessment

              Cardiology—multi-parametric functional and metabolic assessment

              Probe development—’smart’ contrast agents

Application case:


Lawson Research Institute, London Canada

Cubresa has installed a NuPET system in the Lawson Research Institute of London, Ontario, Canada for use in preclinical research. This system is used in the 3T Siemens Biograph. Cubresa provided the mechanical attachment pieces so that the Siemens bed could be used with the PET Insert. The workflow for this system is important. The docking station is located outside of the room due to patient safety issues, and so the cable comes through a plate in the filter panel, through the back of the MRI system, and extends to the front of the MRI where the PET Insert and animal movement system is prepared, as shown in the picture below.

University of Arizona

The University of Arizona has a 7T Bruker system with a 20 cm bore. These systems typically use a BGS- 12A gradient from Bruker, with an inner bore size of 116 mm. The Cubresa NuPET is designed to fit into this MRI, and so no external sleeve was required. Workflow for this system has a NuPET inserted from the back and a bed system inserted from the front.

NuPET™  System Performance:


Paper list:


[1] Dr. Gregory Stortz (2016), “Development of a small animal MR compatible PET insert” (Doctoral Thesis). Department of Physics and Astronomy, University of British Columbia.

[2] Graham Schellenberg (2015), “An algorithm for automatic crystal identification in pixelated scintillation detectors using thin plate splines and Gaussian mixture models” (Master's Thesis). Department of Physics and Astronomy, University of Manitoba.

[3] Ehsan Shams (2014), “A slow control system with gain stabilization for a small animal MR –compatible PET insert” (Master's Thesis)。 Graduate Program in Biomedical Engineering, University of Manitoba。

[4] Chen-Yi Liu (2013), “Characterization of silicon photomultiplier readout designs for us in positron emission tomography systems” (Master's Thesis). Department of Physics & Astronomy, University of Manitoba.

[5] Leonid Lamwertz (2013), “Data acquisition and real-time signal processing in positron emission tomography” (Master's Thesis). Department of Electrical & Computer Engineering, University of Manitoba.

[6] Dr。 Fazal ur-Rehman (2012), “Design and development of detector modules for a highly compact and portable preclinical PET system”, (DoctoralThesis)。 Department of Physics & Astronomy, University of Manitoba。

[7] C. J. Thompson et al., “Comparison of single and dual layer scintillator blocks for preclinical MRI-PET” IEEE Transactions on Nuclear Science, 2012

[8] X。 Zhang et al。, “Development and evaluation of a LOR-based image reconstruction with 3D system response modeling for a PET insert with dual-layer offset crystal design”, Physics in Medicine and Biology, 2013 Dec 7;58(23):8379-99。

[9] "Measurement of energy and timing resolution of very highly pixellated LYSO crystal blocks with multiplexed SiPMreadout for use in a small animal PET/MR insert", Christopher J. Thompson, Andrew L Goertzen, Poitr Kozlowski, Fabrice Retiere, Greg Stortz, Vesna Sossi, Xuezhu Zhang, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC) 2013 IEEE, pp. 1-5, 2013.

[10] “Design and Performance of a resistor multiplexing readout circuit for a SiPMdetector array” Andrew L Goertzen, Xuezhu Zhang, Megan M McClarty, Eric J Berg, Chen-Yi Liu, Piotr Kozlowski, Fabrice Retière, Lawrence Ryner, Vesna Sossi, Greg Stortz, Christopher J Thompson, 2013/6, J。 IEEE Trans。 Nuc。 Sci

[11] G。 Stortz, M。 D。 Walker, C。 J。 Thompson, A。 L。 Goertzen, F。 Retière, X。 Zhang, J。 D。 Thiessen, P。 Kozlowski, and V。 Sossi, "Characterization of a New MR Compatible Small Animal PET Scanner Using Monte-Carlo Simulations," IEEE Trans。 Nucl。 Sci。, vol。 60, no。 3, pp。 1637-1644, Jun。 2013。

[12] “A PET detector interface board and slow control system based on the Raspberry Pi®”, E. Shams et al, Nuc. Sci Symposium and Med Imaging Conference, 2013 IEEE

[13] Thiessen, J.D., Jackson, C., O’Neill, K., Bishop, D., Kozlowski, P., Retière, F., Sossi, V., Stortz, G., Thompson, C.J., & A.L. Goertzen. Performance Evaluation of SensL SiPMArrays for High-Resolution PET. 2013 IEEE Nuclear Science Symposium and Medical Imaging Conference Seoul, Korea, October

27, 2013.

[14] Zhang, X., Thompson, C.J., Thiessen, J.D., & A.L. Goertzen. “Simulations Studies of a Phoswich PET Detector Design with a Two-Fold Improvement in Spatial Sampling” 2013 IEEE Nuclear Science Symposium and Medical Imaging Conference Seoul, Korea, October 27, 2013.

[15] Thiessen, J。D。, Berg, E。, Liu, C。-Y。, Bishop, D。, Kozlowski, P。, Retière, F。, Sossi, V。, Stortz, G。, Thompson, C。J。, Zhang, X。, & A。L。 Goertzen。 MRCompatibility of a SiPM-Based PET Detector Module Using HDMI for Analog Readout and Power Supply。 ISMRM 21st Annual Meeting and Exhibition

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